CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 1,075 enrolled
Drug / intervention
SUZ +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05553366
NCT05553366Phase 3Completed

A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy

Vertex Pharmaceuticals Incorporated·interventional·Posted Sep 23, 2022·Updated Aug 1, 2025

In Brief

A Phase 3 clinical trial evaluating SUZ, HB/APAP, and 2 other interventions for Acute Pain. Completed, enrolled 1,075 participants across 21 sites.

Detailed Summary

The purpose of this study is to evaluate the efficacy and safety of suzetrigine for acute pain after a bunionectomy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Pain
CountriesUnited States
Collaborators--

Timeline

Phase 3CompletedFinished
2023202420252026
First PostedSep 23, 2022
Enrollment StartOct 3, 2022
Primary CompletionDec 15, 2023
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 3.8 years ago

Interventions

SUZdrug

Tablets for oral administration.

HB/APAPdrug

Capsules for oral administration.

Placebo (matched to SUZ)drug

Placebo matched to SUZ for oral administration.

Placebo (matched to HB/APAP)drug

Placebo matched to HB/APAP for oral administration.