CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 35 enrolled
Drug / intervention
Heart-Smile Training Intensive Introduction Program (HST-IIP)behavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05564533
NCT05564533N/ACompleted

Neurophysiological Effects of Interoceptive Compassion Training

Cambridge Health Alliance·interventional·Posted Oct 3, 2022·Updated Jul 11, 2025

In Brief

A clinical study evaluating Heart-Smile Training Intensive Introduction Program (HST-IIP) for Depression. Completed, enrolled 35 participants across 1 site.

Detailed Summary

Heart-Smile Training (HST) is a compassion and loving-kindness-based intensive introduction program consisting of a 3-day retreat, 4-weeks of weekly 2 hour meetings, and a 1-day final retreat. This study is a randomized controlled trial study to evaluate the effectiveness of Heart-Smile Training as compared to the passive control group on measures of neural, physiological, and clinically-relevant outcomes among individuals with symptoms of depression. Participants will be randomized to either the HST group or a waitlist control group. Both groups will complete assessments before and after HST including electroencephalography (EEG), electrocardiogram (EKG), electrodermal activity tests, and self-report surveys. All study activities except surveys will be conducted in person.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
CountriesUnited States

Timeline

N/ACompletedFinished
2023202420252026
First PostedOct 3, 2022
Enrollment StartFeb 9, 2023
Primary CompletionJul 1, 2024
Study CompletionSep 30, 2024
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 3.7 years ago

Interventions

Heart-Smile Training Intensive Introduction Program (HST-IIP)behavioral

Heart-Smile Training (HST) is an interoceptive compassion program designed to develop the qualities of compassion, empathy, and kindness for oneself and others with a focus on interoceptive awareness. It is unique from other compassion trainings in its focus on 1) embodiment of warmth and tenderness of compassionate feeling with a compassionate body scan meditation, 2) development of an "authentic presence," characterized by a warm feeling of loosened attachment to ego-based self, and 3) cultivation of joy triggered by genuine smile to oneself. HST-IIP is a 3-day/4-week/1-day interoceptive compassion program that shares the same core elements and practices as HST 3-day intensive program. Unlike HST, the format of the HST-IIP has an extended duration to develop self-regulation through the cultivation of emotional and behavioral regulation.