At a glance
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Research on the Efficacy and Brain Network Mechanism of Personalized Targeting Intermittent Theta Burst Stimulation (iTBS) Based on Functional Magnetic Resonance Imaging for the Treatment of Major Depressive Disorder
In Brief
A Phase 2 clinical trial evaluating sham iTBS combined with antidepressants and iTBS combined with antidepressants for Depression. Completed, enrolled 68 participants across 1 site.
Detailed Summary
The study will compare the efficacy of intermittent Theta Burst Stimulation (iTBS) with DLPFC-pgACC personalized target for major depressive disorder (MDD) and explore possible brain network mechanisms. The stimulated targets will be located by magnetic resonance imaging (MRI) based on functional MRI based on functional connectivity respectively. This study aims to identify that functional connectivity targeted iTBS protocols on DLPFC-pgACC personalized target have a better antidepressant efficacy compared the sham group and certify that pgACC is an effective potential effector target.
Study Details
Timeline
Interventions
Two sessions of sham prolonged iTBS (1800 pulses) per day over 10 days combined with antidepressants.
Two sessions of prolonged iTBS (1800 pulses) per day over 10 days combined with antidepressants.