CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 61 enrolled / 61 target
Drug / intervention
GEM +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05580978
NCT05580978N/ACompletedOn Track (1.4/mo)Completion was 17mo ago

Libre 2 CGM Plus Glycemic Excursion mIniMization (GEM) in the Treatment of PrEDiabEtes

University of Colorado, Denver·interventional·Posted Oct 14, 2022·Updated Jun 3, 2026

In Brief

A clinical study evaluating GEM and Routine Care for PreDiabetes. Completed, enrolled 61 participants across 1 site.

Detailed Summary

This study is designed to look into the effect of a lifestyle management guide called GEM (Glycemic Excursion Minimization) alongside continuous glucose monitoring (CGM) and an activity monitor (FitBit) and the effect this can have on persons with prediabetes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPreDiabetes
CountriesUnited States

Timeline

N/ACompletedFinished
2023202420252026
First PostedOct 14, 2022
Enrollment StartNov 1, 2022
Primary CompletionJan 15, 2025
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 3.7 years ago

Arms & Interventions

GEM + CGM + Activity Monitorexperimental

GEM plus CGM and Activity Monitor (FitBit)

Behavioral: GEM
Routine Careactive_comparator

Usual care already being received for prediabetes as treated by their care team.

Other: Routine Care

Interventions

GEMbehavioral

The intervention group will be given Libre 2 supplies for 4 months, an activity monitor, and the 4-chapter GEM paper guide. The intervention group will complete a virtual or inperson study visit where they will receive instructions on how to apply their unblinded Freestyle Libre and connect it to the study account, as well as how to register their Fitbit to the study account. Participants will receive one telephone call to review use of the GEM Guide and call at two weeks and six weeks later when the probability of dropouts from lifestyle intervention peaks. Participants will follow the self-directed GEM guide for 4 months (a 1-month treatment period followed by a 3-month maintenance period) while wearing a FitBit activity monitor and a Freestyle Libre 2 CGM.

Routine Careother

Participant's current prediabetes treatment.