CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 10 enrolled
Drug / intervention
3-hydroxybutyrate (3-OHB)dietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

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Search/NCT05581043
NCT05581043N/ACompleted
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Pre-meals of 3-hydroxybutyrate for People With Type 2 Diabetes

University of Aarhus·interventional·Posted Oct 14, 2022·Updated Jan 17, 2024

In Brief

A clinical study evaluating 3-hydroxybutyrate (3-OHB) for Ketosis and 2 related conditions. Completed, enrolled 10 participants across 1 site.

Detailed Summary

Hyperglycemia following meals in patients with type 2 diabetes mellitus (T2DM) is a common problem. Recently, our group found that oral consumption of the ketone metabolite, 3-hydroxybutyrate (3-OHB), effectively stimulates insulin secretion and delays gastric emptying.The aim of this study is to investigate the dose/response relationship between 3-OHB servings of 0, 10, 20 and 40 grams 30 minutes before an OGTT and, ii) investigate the role of timing by serving 20 grams of 3-OHB at different timepoints ahead of an OGTT (0, 30 and 60 minutes)

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsKetosis, Postprandial Hyperglycemia, Glucose Metabolism Disorders (Including Diabetes Mellitus)
CountriesDenmark
CollaboratorsAarhus University Hospital, Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark

Timeline

N/ACompletedFinished
2023202420252026
First PostedOct 14, 2022
Enrollment StartJan 12, 2023
Primary CompletionJan 1, 2024
TodayJul 2, 2026
Enrollment to primary: 12 monthsPosted 3.7 years ago

Interventions

3-hydroxybutyrate (3-OHB)dietary

The aim of this study was therefore to i) investigate the dose/response relationship between 3-OHB servings of 0, 10, 20 and 40 grams 30 minutes before an OGTT and, ii) investigate the role of timing by serving 25 grams of 3-OHB at different timepoints ahead of an OGTT (0, 30 and 60 minutes).