CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 222 enrolled
Drug / intervention
Swab kit (COBAS HPV 4800 Assay -Evalyn brush) +1 moreother
Likely dose
COBAS HPV 4800 Assay with Evalyn brush (patient self-sampling swab kit)AI-extracted
Key inclusion· 2
  • Scheduled appointment at Mayo Clinic Rochester Gynecology Colposcopy Clinic or ICS Colposcopy Clinic (which includes speculum exam)
  • Scheduled appointment at Mayo Clinic Rochester Gynecology Clinic for indication requiring speculum exam (e.g., cervical cancer screening, IUD insertion)
Key exclusion· 6
  • Currently menstruating, pregnant, or within 3 months post-partum
  • History of total hysterectomy (no cervix)
  • Moderate to heavy vaginal bleeding on day of visit
  • Reason for visit is abnormal vaginal discharge

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05600283
NCT05600283N/ACompleted

Validation and Feasibility of Patient Self-sampling of HPV for Cervical Cancer Screening

Mayo Clinic·interventional·Posted Oct 31, 2022·Updated Jan 6, 2026

In Brief

A clinical study evaluating Swab kit (COBAS HPV 4800 Assay -Evalyn brush) and Clinician-collection of cervical sample for HPV testing for Human Papilloma Virus. Completed, enrolled 222 participants across 1 site.

Detailed Summary

The purpose of this study is to validate a patient self-sampling vaginal collection kit and laboratory testing for the detection of HPV (human papillomavirus) infection. Researchers will compare the laboratory results of self-collected vaginal swab samples to usual healthcare provider-collected cervical swab samples to determine the laboratory HPV testing accuracy of the self-collection swab.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedOct 31, 2022
Enrollment StartNov 16, 2022
Primary CompletionJun 4, 2024
TodayJul 2, 2026
Enrollment to primary: 1.6 yearsPosted 3.7 years ago

Interventions

Swab kit (COBAS HPV 4800 Assay -Evalyn brush)other

Patient self-sampling swab kit to collect a vaginal sample for HPV testing

Clinician-collection of cervical sample for HPV testingother

Speculum exam and collection of a cervical specimen using standard endocervical brush and spatula placed into ThinPrep medium for HPV testing (Evalyn brush)