At a glance
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The Impact of Local vs. Systemic Adjuvant Antibiotics During Non-surgical Periodontitis Therapy on Clinical Parameters, Bacterial Count and Cytokine Levels - a Randomized Clinical Trial
In Brief
A clinical study evaluating Piperacillin and Tazobactam in gel form and Amoxicillin and Metronidazole for Periodontitis. Completed, enrolled 38 participants across 1 site.
Detailed Summary
The main treatment of every patient with periodontitis is non-surgical periodontal treatment (NSPT) with the ultimate goal to arrest inflammation. Given the biofilm microorganisms associated etiology of the periodontitis, NSPT can be combined with adjunctive antimicrobial therapy. Hence, this randomized clinical trial aims to compare the clinical and microbiological effectiveness and relative expression levels (REL) of proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) between local and systemic antibiotics as adjunctive therapy to NSPT in patents with periodontitis stage 3.
Study Details
Timeline
Interventions
After non-surgical periodontal treatment, the test group will receive local antibiotics.
After non-surgical periodontal treatment, the control group will receive systemic antibiotics.