At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Doseranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])
In Brief
A Phase 2 clinical trial evaluating OPC 131461 10mg group, OPC 131461 5mg group, and 3 other interventions for Cardiac Edema (CHF). Completed, enrolled 157 participants across 1 site.
Detailed Summary
To investigate the dose response in respect of weight decrease following repeated oral administration of OPC-131461 at 1, 2, 5, and 10 mg or placebo in patients with CHF with volume overload despite having received diuretics other than vasopressin antagonists
Study Details
Timeline
Interventions
OPC-131461 5 mg tablet x 2，once-daily oral administration for 14 days
OPC-131461 5 mg tablet and placebo tablet，once-daily oral administration for 14 days
OPC-131461 1 mg tablet x 2，once-daily oral administration for 14 days
OPC-131461 1 mg tablet and placebo tablet，once-daily oral administration for 14 days
Placebo tablet，once-daily oral administration for 14 days