At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of primary progressive aphasia, logopenic or semantic variant subtype
- ✓PPVT score < -1.0 SD, confirming English language fluency and premorbid cognitive ability
- ✓WAIS-IV Matrix Reasoning T score < 20 to exclude severe cognitive impairment
- ✓Stable and continuous access to internet service and email (WiFi hotspot provided if needed)
- ✕Nonfluent/agrammatic subtype of primary progressive aphasia
- ✕Any disorder other than PPA known to cause language dysfunction
- ✕History of traumatic brain injury
- ✕Uncontrolled seizure disorder or recent (<5 years) history of seizure
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)
In Brief
A Phase 2 clinical trial evaluating Transcranial Direct Current Stimulation (tDCS) and Word-Naming Activity for Primary Progressive Aphasia. Completed, enrolled 11 participants across 1 site.
Detailed Summary
The purpose of this study is to establish the feasibility of a program of remotely supervised transcranial direct current stimulation (RS-tDCS) paired with language skills practice for people living with the semantic or logopenic variants of primary progressive aphasia (PPA). There are currently no established standard-of-care treatments for PPA. This study will evaluate whether RS-tDCS combined with language skills practice is a feasible study design for individuals with PPA.
Study Details
Timeline
Interventions
tDCS is noninvasive brain stimulation device that modulates brain activity by delivering a low-intensity electrical current (2.0 mA) through scalp sponge electrodes. The device is preprogrammed to ramp up to 2.0 mA (for 30 seconds), provide constant current throughout session (29 minutes), and then ramp down (for 30 seconds) at the end.
During each tDCS session, the tDCS clinician will guide the participant in a word-naming exercise. Participants will be presented with photos of target items and prompted to verbally produce the names of the pictures.