At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of cocaine use disorder (CUD)
- ✕Moderate or severe substance use criteria for substances other than cocaine, cannabis, or nicotine
- ✕Unstable psychiatric disorder
- ✕Medical conditions contraindicated to TMS including medical implants, history of seizure or seizure disorder, medications lowering seizure threshold, neurological conditions, or moderate-to-severe heart disease
- ✕Pregnancy
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
In Brief
A clinical study evaluating iTBS to dmPFC and Sham iTBS for Cocaine Use Disorder. Completed, enrolled 6 participants across 1 site.
Detailed Summary
The purpose of this study is to assess the effects of active intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal cortex (dmPFC) on electroencephalogram (EEG) measures of reward sensitivity and cue reactivity and cocaine craving in cocaine users
Study Details
Timeline
Interventions
TMS will be delivered with a MagVenture Mag Pro R30 with the Cool-B70 A/P coil with active liquid cooling and active/sham sides. Approximately 25% of the nasion-inion distance, or Talairah coordinates X 0 Y+60 Z+60 will be measured.The first session will begin with the acquisition of the resting motor threshold (rMT; lowest stimulus intensity that elicits a visible twitch on 50% of the trials) on the contralateral hand. iTBS (triplet 50 Hz bursts, repeated at 5 Hz, 2 sec on and 8 sec off; 600 pulses per session) will be delivered at 110% of the rMT and will last about 3 minutes. Each participant will receive 2 sessions with a 15-20 minute interval between sessions.
Sham TMS will be delivered with the sham side of the MagVenture Cool B70 A/P coil. The software will be pre-programmed by a staff member that will not be involved in data analysis or collection for blinding purposes. The sham stimulation will match the number of pulses and length of time as the active condition and each participant will receive 2 sessions with a 15-20 min interval between sessions.