CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 86 enrolled
Drug / intervention
(CARBAMIDE®) +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05641246
NCT05641246Phase 2Completed
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Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine: A Randomized Controlled Trial.

German University in Cairo·interventional·Posted Dec 7, 2022·Updated Jan 3, 2024

In Brief

A Phase 2 clinical trial evaluating (CARBAMIDE®) and (VOLTAREN®) Emulgel 1% for Hand and Foot Syndrome. Completed, enrolled 86 participants across 1 site.

Detailed Summary

The aim of the study is to evaluate the efficacy of using combination of Urea-based cream (CARBAMIDE®) and topical diclofenac (VOLTAREN®) Emulgel 1% for improving the incidence of Hand-foot syndrome in histologically proven breast cancer Egyptian patients receiving single agent chemotherapy Capecitabine (XELODA ®) and Its effect on improving patients' quality of life.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHand and Foot Syndrome
CountriesEgypt
CollaboratorsCairo University

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedDec 7, 2022
Enrollment StartDec 8, 2022
Primary CompletionNov 15, 2023
Study CompletionDec 8, 2023
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 3.6 years ago

Interventions

(CARBAMIDE®)drug

Urea is used to treat dry/rough skin conditions (such as eczema, psoriasis, corns, callus) and some nail problems (such as ingrown nails). It may also be used to help remove dead tissue in some wounds to help wound healing. Urea is known as a keratolytic. It increases moisture in the skin by softening/dissolving the horny substance (keratin) holding the top layer of skin cells together. This effect helps the dead skin cells fall off and helps the skin keep more water in.

(VOLTAREN®) Emulgel 1%drug

(VOLTAREN®) Emulgel 1% contain the active ingredient diclofenac which belongs to the NSAIDS.it has analgesic and anti-inflammatory properties and due to its alcohol base it has a cooling effect.