CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 240 enrolled
Drug / intervention
Continuous Infusion of ropivacaine +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05642416
NCT05642416Phase 4Completed

Intermittent Bolus Versus Continuous Infusion Erector Spinae Catheters for Median Sternotomy Incisions: A Prospective Randomized Controlled Trial

Henry Ford Health System·interventional·Posted Dec 8, 2022·Updated May 13, 2026

In Brief

A Phase 4 clinical trial evaluating Continuous Infusion of ropivacaine and Intermittent bolus of ropivacaine for Post Operative Pain. Completed, enrolled 240 participants across 1 site.

Detailed Summary

The purpose of this prospective randomized controlled trial is to compare the effectiveness of two different delivery methods for postoperative pain management following cardiac surgery requiring median sternotomy: intermittent programmed LA bolus versus continuous LA infusion through ESP catheters. Effectiveness of analgesia will be assessed based on the subjects' NRS pain scores and opioid consumption. The primary outcome measure will be the patients' opioid consumption over the course of the 72 hours following surgery. Secondary outcomes measures that will be evaluated include NRS pain scores, intensive care unit (ICU) length of stay, and time to first dose of antiemetic in the postoperative period. It is hypothesized that the use of intermittent programmed LA boluses will provide better analgesia compared to continuous LA infusion through ESP catheters. The findings of this study will provide guidance regarding the optimal method of delivery for postoperative pain management in patients following cardiac surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
CollaboratorsAvanos Medical

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedDec 8, 2022
Enrollment StartOct 18, 2022
Primary CompletionDec 23, 2024
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 3.6 years ago

Interventions

Continuous Infusion of ropivacainedrug

Continuous infusion of ropivacaine

Intermittent bolus of ropivacainedrug

Intermittent bolus of ropivacaine