CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 30 enrolled
Drug / intervention
Lepidium Sativum +1 moredrug
Likely dose
Lepidium Sativum 2 mlfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05657015
NCT05657015Phase 4Completed
CompareCT.gov

Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy: A Randomized Controlled Clinical Trial With Biochemical Analysis

Ain Shams University·interventional·Posted Dec 20, 2022·Updated Dec 20, 2022

In Brief

A Phase 4 clinical trial evaluating Lepidium Sativum and Simvastatin for Periodontitis. Completed, enrolled 30 participants across 1 site.

Detailed Summary

The objectives of this clinical study were to: 1. Assess the influence of Lepidium sativum in situ gel versus simvastatin gel on the clinical parameters in periodontitis patients as the primary objective. 2. Detect the effect of locally delivered Lepidium sativum and simvastatin gels on the nuclear factor kappa B (NF-κB) level in gingival crevicular fluid as the secondary objective.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPeriodontitis
CountriesEgypt
Collaborators--

Timeline

Phase 4CompletedFinished
20222023202420252026
First PostedDec 20, 2022
Enrollment StartSep 1, 2021
Primary CompletionMay 1, 2022
Study CompletionJul 1, 2022
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 3.5 years ago

Interventions

Lepidium Sativumdrug

2 ml of LS in situ gel at baseline

Simvastatindrug

1.2% of SMV in situ gel at baseline