CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 28 enrolled
Drug / intervention
Sweet licorice +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05661721
NCT05661721N/ACompleted
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Licorice and Home Blood Pressure: a Randomized Crossover Trial

Linkoeping University·interventional·Posted Dec 22, 2022·Updated Aug 28, 2023

In Brief

A clinical study evaluating Sweet licorice and Salty licorice for Hypertension,Essential. Completed, enrolled 28 participants across 1 site.

Detailed Summary

Out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. The aim of this study is to analyze the association between licorice intake and home blood pressure.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension,Essential
CountriesSweden
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedDec 22, 2022
Enrollment StartJan 30, 2023
Primary CompletionJun 30, 2023
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 3.5 years ago

Interventions

Sweet licoriceother

Ecologic, vegan and gluten free, low-sodium sweet licorice pastilles made from Glycyrrhiza glabra, with a manufacturer specified content of 4% sugars, 2% glycyrrhizin and 0.03% salt, will be used as intervention. The exact glycyrrhizin content will be determined before the study begins, and participants will be instructed to consume a daily licorice dose that is equivalent to 100 mg of glycyrrhizin.

Salty licoriceother

A vegan and gluten free salty licorice without glycyrrhizin, flavored with ammonium chloride, with a manufacturer specified content of 0% sugars and 0.05% salt, will be used as control. The amount of salty licorice will be the same as for sweet licorice, and thus determined after the glycyrrhizin content analysis of the sweet licorice.