CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 92 enrolled
Drug / intervention
Calcium pre-treatment +1 moredrug
Likely dose
Calcium pre-treatment 100mlfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05661942
NCT05661942Phase 4Completed
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Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate (AFF RVR): Comparing Calcium Pre-treatment vs Placebo in Prevention of Diltiazem Induced Hypotension

Wake Forest University Health Sciences·interventional·Posted Dec 22, 2022·Updated Nov 10, 2025

In Brief

A Phase 4 clinical trial evaluating Calcium pre-treatment and Placebo for Atrial Fibrillation With Rapid Ventricular Response and Hypotension Drug-Induced. Completed, enrolled 92 participants across 1 site.

Detailed Summary

The purpose of this study is to see how well calcium pre-treatment works for decreasing incidence of drug-induced hypotension after diltiazem administration for treatment of atrial flutter with rapid ventricular rate.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAtrial Fibrillation With Rapid Ventricular Response, Hypotension Drug-Induced
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedDec 22, 2022
Enrollment StartNov 30, 2022
Primary CompletionNov 20, 2024
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 3.5 years ago

Interventions

Calcium pre-treatmentdrug

The intervention is Calcium gluconate 1 gram/100ml 0.9% NaCl or 100ml 0.9% NaCl) over 5 minutes.

Placeboother

Placebo/ no calcium pre-treatment.