CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 116 enrolled / 116 target
Drug / intervention
Youth Friendship Bench SAbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05664490
NCT05664490N/ACompletedHigh Momentum (3.0/mo)Completion was 28mo ago
CompareCT.gov

Youth Friendship Bench SA: Optimization of the Friendship Bench Mental Health Intervention for Adolescent Girls and Young Women in South African PrEP Delivery Settings

University of California, San Francisco·interventional·Posted Dec 23, 2022·Updated Jun 26, 2026

In Brief

A clinical study evaluating Youth Friendship Bench SA for Depression and Pre-Exposure Prophylaxis. Completed, enrolled 116 participants across 1 site.

Signals

Enrolling ahead of pace

Detailed Summary

Adolescent girls and young women (AGYW) at risk of HIV in sub-Saharan Africa, frequently (20-50%) have symptoms of common mental disorders, including depression, anxiety, and stress. These symptoms are associated with suboptimal adherence to HIV pre-exposure prophylaxis (PrEP), a highly effective HIV prevention approach. In this project, the team seeks to address poor mental health and consequent impacts on PrEP adherence and among AGYW at risk of HIV by testing an evidence-based mental health intervention (the Youth Friendship Bench SA) adapted for PrEP delivery programs.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression, Pre-Exposure Prophylaxis
CountriesSouth Africa
CollaboratorsNational Institute of Mental Health (NIMH), University of Witwatersrand, South Africa

Timeline

N/ACompletedFinished
2023202420252026
First PostedDec 23, 2022
Enrollment StartApr 3, 2023
Primary CompletionFeb 9, 2024
TodayJul 2, 2026
Enrollment to primary: 10 monthsPosted 3.5 years ago

Arms & Interventions

Standard-of-Care Mental Health Servicesno_intervention

Participants randomized to this group will receive standard-of-care mental health services as specified in the South African Department of Health Adult Primary Care Guidelines.

Youth Friendship Bench SA + Standard-of-Careexperimental

Participants randomized to this group will receive the Youth Friendship Bench SA intervention in addition to standard-of-care mental health services as specified in the South African Department of Health Adult Primary Care Guidelines.

Behavioral: Youth Friendship Bench SA

Interventions

Youth Friendship Bench SAbehavioral

The intervention includes: 5 individual counseling sessions; one optional in-person or WhatsApp-based group counseling session; optional remote counseling sessions; and optional one-way SMS messages to provide reminders about upcoming visits. During the initial session, participants will meet with the trained counselor to discuss mental health challenges, identify problems in their life that affect their mental health and PrEP use, generate alternative solutions, make decisions about the alternatives, and collaboratively decide on a plan to implement the solutions. During follow-up counseling sessions, participants will discuss progress in implementing solutions to address the problems they identified in prior sessions with the lay counselor. They will also discuss any other mental health challenges and problems in their life that affect their mental health and PrEP use which they would like to address.