At a glance
ClinicalIndex Comparison Record- ✓Knee pain on most days for >3 months
- ✓Age >18 years
- ✓BMI 18.5–39.9 kg/m²
- ✓Willing and able to give informed consent
- ✕Psychosocial or gastrointestinal conditions (IBS/IBD, coeliac)
- ✕Taking immunosuppressants, anticoagulants, amiodarone, or perhexiline
- ✕Pregnant or breast feeding
- ✕History or current psychiatric illness
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Molecular Signatures of Endocannabinoid Induced Pain Relief in Humans: Lifestyle Interventions, Systemic and Localised Changes
In Brief
A clinical study evaluating Inulin Fibre supplement, Maltodextrin (Placebo), and 1 other intervention for Osteoarthritis, Knee. Completed, enrolled 117 participants across 1 site.
Detailed Summary
This is a 2x2 factorial design randomised controlled trial in which participants with knee pain will be grouped into the diet intervention, exercise intervention, diet and exercise intervention or placebo arm. The study involves intake of dietary supplements and performing routine exercises which are commonly used and are not pharmacological agents. N= 117. 2x2 intervention with individuals per block: placebo (n=27), diet only (n=26), exercise only (n=40), diet + exercise (n=24)
Study Details
Timeline
Interventions
20g/ day. Inulin is easily dissolvable in liquid and can be incorporated into the usual diet - by adding to water, juice, smoothies, cereal, yogurt etc.
10g/ day which can be consumed by adding to breakfast cereal/ smoothie/ yogurt or drink of choice
Joint Academy An app-based exercises platform (Joint Academy®) will be used as an intervention given to the treatment arm. The programme consists of a mixture of open and close chain exercises, a combination of concentric, eccentric and focusing on the global strength of legs including the muscles around the hips and knee joints as well as balance enhancement exercises.