At a glance
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The Impact of Pre-operative Olanzapine on Quality of Recovery-40 Scores After Discharge From Ambulatory Surgery
In Brief
A Phase 2 clinical trial evaluating Olanzapine and Placebo for Postoperative Nausea and Vomiting. Completed, enrolled 384 participants across 1 site.
Detailed Summary
The primary objective of this phase 2 randomized controlled trial is to determine whether the pre-operative administration of olanzapine (5 mg PO) improves quality of recovery (assessed by the Quality of Recovery-40 (QoR-40) survey) on postoperative day 1 in patients having ambulatory surgery with general anesthesia. The secondary objectives of this study are to determine whether there are differences in quality of recovery on postoperative day 2, presence of post-discharge nausea, presence of severe post-discharge nausea, recovery room length of stay and opioid consumption in patients who receive the study drug versus placebo.
Study Details
Timeline
Interventions
5 mg of oral olanzapine one hour prior to ambulatory surgery
oral matched placebo one hour prior to ambulatory surgery