CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 31 enrolled
Drug / intervention
Pecto-intercostal Fascial Block (PIFB) +1 moredrug
Likely dose
Bupivacaine with epinephrine; with or without clonidine and dexamethasone via pecto-intercostal fascial blockAI-extracted
Key inclusion· 1
  • Adults undergoing cardiac surgery involving sternotomy
Key exclusion· 12
  • History of allergy to amide local anesthetics or any perineural adjuvants
  • Existing neurologic deficit in the chest wall
  • Remaining intubated 6 hours after block placement
  • Weight under 50 kg

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05676814
NCT05676814Phase 4Completed

Pecto-intercostal Fascial Block With Perineural Adjuvants for Postoperative Analgesia Following Sternotomy in Patients Undergoing Cardiac Surgery

Wake Forest University Health Sciences·interventional·Posted Jan 9, 2023·Updated Jun 11, 2024

In Brief

A Phase 4 clinical trial evaluating Pecto-intercostal Fascial Block (PIFB) and PIFB with adjuvants for Analgesia and Sternotomy. Completed, enrolled 31 participants across 1 site.

Detailed Summary

The purpose of this randomized, triple-blinded, prospective, feasibility study is to compare postoperative analgesia provided by Pecto-intercostal Fascial Block (PIFB) when performed with local anesthetic solution with or without perineural adjuvants in patients following cardiac surgery involving sternotomy. The study team hypothesizes that the patients receiving PIFB with bupivacaine with epinephrine, clonidine, and dexamethasone will have lower dynamic pain over the first 36 hours compared to those receiving PIFB with just bupivacaine and epinephrine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedJan 9, 2023
Enrollment StartMar 24, 2023
Primary CompletionJun 23, 2023
Study CompletionJun 24, 2023
TodayJul 2, 2026
Enrollment to primary: 3 monthsPosted 3.5 years ago

Interventions

Pecto-intercostal Fascial Block (PIFB)drug

PIFB done with bupivacaine and epinephrine

PIFB with adjuvantsdrug

PIFB with bupivacaine, epinephrine, clonidine, and dexamethasone