At a glance
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Methylation Detection of KCNA3 and OTOP2 Genes in Plasma for the Auxiliary Diagnosis of Esophageal Cancer/Precancerous Lesions: a Clinical Trial
In Brief
An observational study evaluating KCNA3 and OTOP2 Gene Methylation Combined Detection Kit (Fluorescent PCR Method) for Esophageal Neoplasms. Completed, enrolled 1,116 participants across 1 site.
Detailed Summary
The goal of this observational study is to test the clinical efficacy of "KCNA3 and OTOP2 gene methylation combined detection kit (fluorescence PCR method)"in esophageal cancer and high-grade esophageal neoplasia auxiliary diagnosis.The main questions it aims to answer are: 1. How consistent are the test results of the kit with the clinical reference diagnostic criteria? 2. Sanger sequencing can visually show whether each sample contains methylation sites, so in this clinical trial, the kit results were compared with Sanger sequencing results to analyze the reagent's accuracy in detecting KCNA3 and OTOP2 gene methylation. Each participant is required to provide no less than 10 ml of blood to complete the kit test.
Study Details
Timeline
Interventions
Blood samples from participants in both groups were collected and methylation tests were performed according to the kit instructions.