CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 71 enrolled
Drug / intervention
Placebo +2 moredrug
Likely dose
TAK-861 2 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05687916
NCT05687916Phase 2Completed

A Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-861 for the Treatment of Narcolepsy Without Cataplexy (Narcolepsy Type 2)

Takeda·interventional·Posted Jan 18, 2023·Updated Jan 9, 2025

In Brief

A Phase 2 clinical trial evaluating Placebo, TAK-861 2 mg, and 1 other intervention for Narcolepsy Type 2. Completed, enrolled 71 participants across 56 sites in 12 countries.

Detailed Summary

The main aim is to evaluate the effect of TAK-861 on symptoms of narcolepsy, including excessive daytime sleepiness (EDS) as measured by sleep latency from the Maintenance of Wakefulness Test (MWT). The study will enroll approximately 60 participants and they will be randomly assigned to 3 groups (20 per group) to take one of two different doses of TAK-861 or a placebo. All the participants will receive the treatment for 8 weeks. Participants will be asked to complete some questionnaires during the study. This trial will be conducted in North America, Europe, and Asia Pacific.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Finland, France, Germany, Italy, Japan, Netherlands, Norway, Spain, Sweden, Switzerland, United States
Collaborators--

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedJan 18, 2023
Enrollment StartJan 9, 2023
Primary CompletionDec 13, 2023
Study CompletionDec 25, 2023
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 3.5 years ago

Interventions

Placebodrug

TAK-861 placebo matching tablets.

TAK-861 2 mgdrug

TAK-861 2 mg tablets.

TAK-861 2 mg and 5 mgdrug

TAK-861 2 mg and 5 mg tablets.