CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 3 enrolled
Drug / intervention
OXU-001 +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05697809
NCT05697809Phase 2Completed

A Multi-Center, Randomized, Parallel-Group, Phase 2, Masked, Three-Arm Trial to Compare Safety, Tolerability, Efficacy, and Durability of Two Dose Levels of Suprachoroidal Sustained-Release OXU-001 (Dexamethasone Microspheres; DEXAspheres®) Using the Oxulumis® Illuminated Microcatheterization Device Compared With Intravitreal Dexamethasone Implant (OZURDEX®) in Subjects With Diabetic Macular Edema (OXEYE)

Oxular Limited·interventional·Posted Jan 26, 2023·Updated Sep 3, 2025

In Brief

A Phase 2 clinical trial evaluating OXU-001, Semi-automated suprachoroidal illuminated microcatheter, and 1 other intervention for Diabetic Macular Edema. Completed, enrolled 3 participants across 9 sites in 2 countries.

Detailed Summary

The purpose of this clinical trial is to compare safety, tolerability, efficacy, and durability of two dose levels of suprachoroidal sustained-release OXU-001 (dexamethasone microspheres; DEXAspheres®) using the Oxulumis® illuminated microcatheterization device compared with intravitreal dexamethasone implant (OZURDEX®) in subjects with diabetic macular edema.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesPuerto Rico, United States
Collaborators--

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedJan 26, 2023
Enrollment StartAug 7, 2023
Primary CompletionDec 5, 2024
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 3.4 years ago

Interventions

OXU-001drug

Suprachoroidal sustained release dexamethasone acetate

Semi-automated suprachoroidal illuminated microcatheterdevice

Ophthalmic administration device

Ozurdex® Ophthalmic Intravitreal Implantdrug

Ophthalmic dexamethasone intravitreal implant