CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 81 enrolled
Drug / intervention
Systane Complete PF +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05705518
NCT05705518Phase 4Completed
CompareCT.gov

Effects Of Artificial Tears on Tear Lipid Films and Tear Film Dynamics In Vivo

University of California, Berkeley·interventional·Posted Jan 30, 2023·Updated Mar 14, 2025

In Brief

A Phase 4 clinical trial evaluating Systane Complete PF, Refresh Relieva PF, and 2 other interventions for Dry Eye. Completed, enrolled 81 participants across 1 site.

Detailed Summary

Dry eye disease (DED) is pervasive with some reports estimating over 16 million adults diagnosed in the United States. Currently, artificial tears remain an integral part of managing dry eyes and are mainly used for symptomatic relief. Recent studies have shown there may be therapeutic benefits with regular use of lipid-based artificial tears to improve the structure of the tear film, which may improve tear film stability and provide relief of symptoms. In this study the investigators propose to compare effects on the tear lipid film and its dynamics between 3 lipid based artificial tears and a widely available non-lipid based artificial tear.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDry Eye
CountriesUnited States
CollaboratorsAlcon Research

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedJan 30, 2023
Enrollment StartJan 30, 2023
Primary CompletionSep 30, 2023
Study CompletionJan 30, 2024
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 3.4 years ago

Interventions

Systane Complete PFdrug

3 month use, 4 times daily, of Systane Complete PF, a lipid-based, preservative-free artificial tear product

Refresh Relieva PFdrug

3 month use, 4 times daily, of Refresh Relieva PF, a non-lipid-based, preservative-free artificial tear product

Refresh Optive Mega-3 PFdrug

3 month use, 4 times daily, of Refresh Optive Mega-3 PF, a lipid-based, preservative-free artificial tear product

CVS Health Lubricant Eye Drop (PG 0.6%)drug

3 month use, 4 times daily, of CVS Health Lubricant Eye Drop (PG 0.6%), a lipid-based, preserved artificial tear product