CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 30 enrolled
Drug / intervention
Brolucizumab +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05710471
NCT05710471Phase 4Completed

Treatment of Recalcitrant Neovascular AMD Using Brolocizumab With a Novel Treat and Extend Protocol - a Randomized Controlled Prospective Study

The University of Hong Kong·interventional·Posted Feb 2, 2023·Updated May 8, 2024

In Brief

A Phase 4 clinical trial evaluating Brolucizumab and Aflibercept for Age-Related Macular Degeneration. Completed, enrolled 30 participants across 1 site.

Detailed Summary

The investigator propose to conduct a randomized clinical trial, investigating the safety and efficacy of brolucizumab for treatment of nAMD patients with CNV, and plans to specifically target those who are not responding to standard Treat and Extend (T\&E) treatment. A randomised omized study will be conducted with 2 arms, one with the new drug (brolocizumab) and novel treatment protocol versus a second arm using the current gold standard of aflibercept and the T\&E protocol

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesHong Kong
Collaborators--

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedFeb 2, 2023
Enrollment StartJul 25, 2022
Primary CompletionJul 25, 2023
Study CompletionAug 30, 2023
TodayJul 2, 2026
Enrollment to primary: 1 yearPosted 3.4 years ago

Interventions

Brolucizumabdrug

Intravitreal injection

Afliberceptdrug

Intravitreal injection