At a glance
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A Randomized Trial of the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele Sac Repair
In Brief
A clinical study evaluating Use of Platelet-Rich Plasma after meningomyelocele sac repair and meningomyelocele sac repair for Meningomyelocele/Spina Bifida. Completed, enrolled 40 participants across 1 site.
Detailed Summary
Introduction: Meningomyelocele is a common congenital neural tube defect. To reduce complications, early surgery and a multidisciplinary approach is needed. In this study, the investigators administered platelet-rich plasma (PRP) to newborns with meningomyelocele following corrective surgery to minimize cerebrospinal fluid (CSF) leakage and accelerate the healing of the immature pouch tissue. The investigators compared these with a control group that did not receive PRP. Patients and Methods: Of the 40 newborns who were operated on with the diagnosis of meningomyelocele, 20 patients received PRP after surgical repair, and 20 were followed up without PRP. In the PRP group, 10 of the 20 patients underwent primary defect repair, the other 10 underwent flap repair. In the group that did not receive PRP, primary closure was performed in 14 patients and flap closure in six.
Study Details
Timeline
Interventions
Wound healing with the use of Platelet-Rich Plasma after surgical meningomyelocele pouch repair
meningomyelocele sac repair without Platelet-Rich Plasma