CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 333 enrolled
Drug / intervention
Weight discrimination experience +1 morebehavioral
Likely dose
Not stated in record
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Search/NCT05714696
NCT05714696N/ACompleted

Mechanisms Explaining the Link Between Weight Discrimination and Poor Cardiovascular Health

Florida State University·interventional·Posted Feb 6, 2023·Updated May 15, 2025

In Brief

A clinical study evaluating Weight discrimination experience and Control experience for Obesity. Completed, enrolled 333 participants across 1 site.

Detailed Summary

People with obesity regularly experience discrimination on the basis of their body weight and such experiences are associated with increased risk for poor cardiovascular health. The goal of this clinical trial is to identify cognitive, affective, behavioral, and physiological factors that explain the relationship between weight discrimination and poor health outcomes. A diverse sample of adults with obesity will be randomly assigned to a social interaction encounter that simulates a typical weight discrimination experience (experimental manipulation) vs. a control manipulation that does not involve discrimination. The investigators will examine the immediate effects of the experimental manipulation on cognitive (e.g., self-regulation), affective (e.g., negative emotion), behavioral (e.g., comfort eating), and physiological (e.g., cortisol secretion) outcomes. Two additional aims of the study are to identify psychological traits that moderate responses to weight discrimination and to assess whether the negative health effects of weight discrimination differ by age, sex/gender, race, or ethnicity.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsObesity
CountriesUnited States

Timeline

N/ACompletedFinished
202420252026
First PostedFeb 6, 2023
Enrollment StartFeb 5, 2023
Primary CompletionApr 26, 2024
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 3.4 years ago

Interventions

Weight discrimination experiencebehavioral

In the experimental condition, participants will learn that their group members are biased against overweight people but not elderly or racial/ethnic minority individuals, as indicated by the "getting to know you" summary ratings handout. Participants will also receive negative feedback about their personal attributes by being labeled with negative weight-based stereotypes. Although some ratings will be positive (e.g., they will receive high ratings on being friendly and kind), participants will be rated poorly on attributes viewed as necessary to develop a strong marketing campaign (i.e., motivation to work hard, possessing self-discipline to persist at the task, and competence). After (ostensibly) assembling the group's preferences, the experimenter will inform participants that no one selected them to be their partner, thus they will perform the next few tasks alone. This manipulation has been shown to prompt feelings of social exclusion.

Control experiencebehavioral

In the control condition, participants will learn that their group members have positive attitudes toward people with higher body weight, as well as elderly and racial/ethnic minority individuals, as indicated by the "getting to know you" summary ratings handout. Participants will also receive positive feedback about their personal attributes, as indicated by the summary ratings averaged across the three members. Finally, participants in the control condition will be told that one of their group members had to leave unexpectedly for a family emergency, so pairs cannot be assembled as usual, thus they will perform the next few tasks alone. This manipulation should not prompt feelings of social exclusion.