At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 116 enrolled
Drug / intervention
Dexmedetomidine +1 moredrug
Likely dose
Dexmedetomidine 0.5 microgramsfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of Prophylactic Use of Dexmedetomidine and Ketamine for Prevention of Shivering After Spinal Anesthesia
In Brief
A Phase 4 clinical trial evaluating Dexmedetomidine and Ketamine for Postoperative Shivering. Completed, enrolled 116 participants across 1 site.
Detailed Summary
Recently, ketamine and dexmedetomidine have been used to prevent shivering during anaesthesia, with good results. Ketamine (a competitive NMDA receptor antagonist) plays a role in thermoregulation at various levels and ketamine, has been shown to inhibit postoperative shivering in some reports and studies.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Shivering
CountriesPakistan
Collaborators--
Timeline
Phase 4CompletedFinished
202120222023202420252026
Enrollment StartFeb 2021
Primary CompletionAug 2021
First PostedFeb 2023
TodayJul 2026
First PostedFeb 8, 2023
Enrollment StartFeb 20, 2021
Primary CompletionAug 19, 2021
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 3.4 years ago
Interventions
Dexmedetomidinedrug
0.5 micrograms/kg diluted in 10mL of normal saline 0.9% given as IV infusion over 10 minutes
Ketaminedrug
0.5 milligrams/kg diluted in 10mL of normal saline 0.9% given as IV infusion over 10 minutes