CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 17 enrolled
Drug / intervention
Velusetrag 15 mg once daily for 4 weeks. +1 moredrug
Likely dose
Velusetrag 15 mg once daily for 4 weeks.from record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05724069
NCT05724069Phase 2Completed
CompareCT.gov

Velusetrag for the Treatment of Chronic Intestinal Pseudo-Obstruction (CIPO). A Multicenter, Double-blind, Placebo-controlled, Cross-over, Multiple (n=1) Trial.

Alfasigma S.p.A.·interventional·Posted Feb 13, 2023·Updated Aug 3, 2025

In Brief

A Phase 2 clinical trial evaluating Velusetrag 15 mg once daily for 4 weeks. and Placebo once daily for 4 weeks. for Chronic Intestinal Pseudo-obstruction. Completed, enrolled 17 participants across 4 sites in 3 countries.

Detailed Summary

This is a phase II, multicenter, double-blind, placebo-controlled trial to evaluate the efficacy and safety of velusetrag once a day, compared to placebo, in subjects with CIPO.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Intestinal Pseudo-obstruction
CountriesBelgium, Italy, Spain
Collaborators--

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedFeb 13, 2023
Enrollment StartDec 15, 2021
Primary CompletionApr 12, 2023
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 3.4 years ago

Interventions

Velusetrag 15 mg once daily for 4 weeks.drug

Subjects will be randomly allocated in a blinded fashion to 1 out of the 4 treatment sequences (each sequence include 4 periods, 2 periods with velusetrag and 2 periods with placebo). There will be a wash-out period between each treatment period.

Placebo once daily for 4 weeks.drug

Subjects will be randomly allocated in a blinded fashion to 1 out of the 4 treatment sequences (each sequence include 4 periods, 2 periods with velusetrag and 2 periods with placebo). There will be a wash-out period between each treatment period.