CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 181 enrolled
Drug / intervention
Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT studyother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05746819
NCT05746819N/ACompleted
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An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)

University of Rochester·observational·Posted Feb 28, 2023·Updated Apr 15, 2024

In Brief

An observational study evaluating Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT study for Brain Injuries and 5 related conditions. Completed, enrolled 181 participants across 2 sites in 2 countries.

Detailed Summary

This study will seek consent from parents of children enrolled in the Malaria FEVER study to obtain neuroimaging and 12-month neuropsychiatric outcomes data and kidney function on their child. The imaging and evaluations for this observational study will occur after the child has recovered from the acute malaria infection and has otherwise completed the RCT intervention and safety evaluations.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsBrain Injuries, Malaria, MRI Imaging, Neurocognitive Deficits, Chronic Kidney Diseases, Behavior Problem
CountriesMalawi, Zambia
CollaboratorsNational Institute of Neurological Disorders and Stroke (NINDS)

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedFeb 28, 2023
Enrollment StartJan 2, 2021
Primary CompletionAug 31, 2023
Study CompletionMar 31, 2024
TodayJul 2, 2026
Enrollment to primary: 2.7 yearsPosted 3.3 years ago

Interventions

Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT studyother

After clinical trial of the Malaria RCT study, this study will compare children allocated to aggressive antipyretic therapy vs. usual care on the prevalence of structural brain abnormalities after recovery from CNS malaria.