CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 100 enrolled
Drug / intervention
Conservative treatment Arm +1 morecombination
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05756647
NCT05756647Phase 2Completed
CompareCT.gov

Mandibular Advancement vs Home Treatment for Primary Snoring: A Randomized Trial (SNORE-LESS)

Washington University School of Medicine·interventional·Posted Mar 6, 2023·Updated Jun 6, 2025

In Brief

A Phase 2 clinical trial evaluating Interventional Arm and Conservative treatment Arm for Snoring. Completed, enrolled 100 participants across 1 site.

Detailed Summary

This is a randomized controlled trial for non-apneic snorers. The primary goal of the study is to evaluate the efficacy of a mandibular advancement device (MAD) vs conservative treatment for adults with non-apneic snoring as measured by the partners report of response to treatment (CGI-I). The secondary goal is to evaluate the effectiveness of treatment of snoring on the Epworth Sleepiness Scale (ESS), a modified Symptoms of Nocturnal Obstruction and Related Events (SNORE-25) questionnaire, the Pittsburgh Sleep Quality Index (PSQI), and the Clinical Global Impression of Severity Scale (CGI-S)

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSnoring
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedMar 6, 2023
Enrollment StartNov 7, 2022
Primary CompletionJul 3, 2023
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 3.3 years ago

Interventions

Interventional Armdevice

The MAD arm will consist of participants given a fitted mandibular advancement device that they will wear for the length of the study.

Conservative treatment Armcombination

Participant will undergo a nightly medicated nasal rinse that will occur for a 4 week period, prior to beginning of the other three conservative therapy interventions. The 4-part combination therapy will take place for 4 weeks total.