CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 817,337 enrolled
Drug / intervention
Propranolol or Carvedilol +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05794997
NCT05794997N/ACompleted
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Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol

Brigham and Women's Hospital·observational·Posted Apr 3, 2023·Updated Nov 10, 2025

In Brief

An observational study evaluating Propranolol or Carvedilol and Atenolol, Bisoprolol or Sotalol for Hypertension. Completed, enrolled 817,337 participants across 1 site.

Detailed Summary

This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA), Rutgers University, Johns Hopkins University

Timeline

N/ACompletedFinished
2023202420252026
First PostedApr 3, 2023
Enrollment StartNov 30, 2022
Primary CompletionJan 1, 2023
Study CompletionDec 31, 2023
TodayJul 2, 2026
Enrollment to primary: 1 monthPosted 3.2 years ago

Interventions

Propranolol or Carvediloldrug

Propranolol or Carvedilol claim is used as the exposure group.

Atenolol, Bisoprolol or Sotaloldrug

Atenolol, Bisoprolol or Sotalol claim is used as the reference group.