CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 7 enrolled
Drug / intervention
Ketamine Hydrochloride +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05796791
NCT05796791Early Ph 1Completed
CompareCT.gov

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Medical University of South Carolina·interventional·Posted Apr 4, 2023·Updated Jul 18, 2025

In Brief

A Early Phase 1 clinical trial evaluating Ketamine Hydrochloride and Motivational enhancement therapy for Tobacco Use and 2 related conditions. Completed, enrolled 7 participants across 1 site.

Detailed Summary

The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for tobacco use disorder when delivered in conjunction with brief motivational enhancement therapy. Participants will receive ketamine assisted motivational enhancement therapy weekly for three weeks and there will be 2 follow up visits. All visits will also consist of questionnaires and saliva samples will be taken. The overall participation will last approximately 8 weeks.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTobacco Use, Smoking Cessation, Nicotine Dependence
CountriesUnited States
Collaborators--

Timeline

Early Ph 1CompletedFinished
202420252026
First PostedApr 4, 2023
Enrollment StartMay 2, 2023
Primary CompletionJun 30, 2024
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 3.2 years ago

Interventions

Ketamine Hydrochloridedrug

IM ketamine given in weekly session for a total of 3 weeks

Motivational enhancement therapybehavioral

Brief motivational based therapy