At a glance
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Does Bedside Ultrasound Clot Elasticity Measurement Reduce Intraoperative Transfusion During Double-lung Transplantation?
In Brief
A clinical study evaluating Quantra and Control for Lung Diseases and Transplant-Related Disorder. Completed, enrolled 128 participants across 1 site.
Signals
Detailed Summary
Transfusion in lung transplantation is common, and despite improved techniques and limitations in the use of mechanical circulatory support (MCS), the incidence of massive transfusion has remained stable over the years. The consequences of blood transfusion (blood cells, plasma, platelet concentrates) are deleterious for patients and increase primary graft dysfunction and mortality risk. Whole blood viscoelastic testing devices have shown its effectiveness in monitoring coagulation and fibrinolytic function during cardiac surgery, liver transplantation or trauma. So far, few delocalized biology tools have been evaluated in lung transplantation. The main objective of this study is to determine if the use of a transfusion algorithm based on whole blood viscoelastic test with Quantra® test reduce transfusion during lung transplantation.
Study Details
Timeline
Arms & Interventions
Adult subjects (18 years-old or older) undergoing double-lung transplantation: transfusion algorithm based on whole blood viscoelastic test with Quantra® + standard coagulation test. These samples are collected at five standard surgical time points: * on arrival at the hospital on the day of surgery, * after first pulmonary artery clamping, * after first graft implantation, * after second graft implantation, * at end-surgery status.
Adult subjects (18 years-old or older) undergoing double-lung transplantation: standard transfusion algorithm based on standard practice and coagulation test. These samples are collected at five standard surgical time points: * on arrival at the hospital on the day of surgery, * after first pulmonary artery clamping, * after first graft implantation, * after second graft implantation, * at end-surgery status.
Interventions
The study plans to collect 2 additional 3 mL citrate tubes of venous blood in addition to the platelet and blood counts.
The study plans to collect 1 additional 3 mL citrate tubes of venous blood in addition to the platelet and blood counts at each time.