CI

At a glance

ClinicalIndex Comparison Record
Phase 4Recruiting· 700 target
Drug / intervention
AAA617drug
Likely dose
Not stated in record
Key inclusion· 3
  • Signed informed consent prior to study participation
  • Prior AAA617 treatment in Novartis-sponsored Phase I-IV prostate cancer trial
  • Met prior trial requirements allowing continuation to this study
Key exclusion· 1
  • Unable to complete required investigational examinations

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05803941
NCT05803941Phase 4RecruitingHigh Momentum

A Phase IV, Post-Authorization Safety Study to Investigate the Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Adult Participants With Prostate Cancer

Novartis Pharmaceuticals·interventional·Posted Apr 7, 2023·Updated Jun 4, 2026

In Brief

A Phase 4 clinical trial evaluating AAA617 for Prostate Cancer. Currently recruiting, targeting 700 participants across 54 sites in 11 countries.

Signals

Enrolling ahead of pace

Detailed Summary

The purpose of this post-marketing study is to further characterize the long-term outcome of known or potential risks of lutetium (177Lu) vipivotide tetraxetan also known as \[177Lu\]Lu-PSMA-617 or 177Lu-PSMA-617 and hereinafter referred to as AAA617. The study also seeks to further characterize (as possible) any other AAA617 causally related serious adverse event(s) in the long-term in adults with prostate cancer who received at least one dose of AAA617 from interventional, Phase I-IV Novartis sponsored clinical trials.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsProstate Cancer
CountriesAustria, Belgium, Canada, Czechia, France, Germany, Netherlands, Spain, Sweden, United Kingdom, United States
Collaborators--

Timeline

Phase 4Recruiting
20232024202520262027202820292030203120322033
First PostedApr 7, 2023
Enrollment StartAug 14, 2023
Primary CompletionJul 20, 2033
Study CompletionJul 21, 2033
TodayJul 2, 2026
Enrollment to primary: 9.9 yearsPosted 3.2 years agoPrimary completion in 7.0 years

Arms & Interventions

Single armother

Participants will be followed until death, lost to follow-up, or up to 10 years from first dose of AAA617, whichever occurs first. There will be no study treatment administered to participants while participating in this study.

Drug: AAA617

Interventions

AAA617drug

Long-term follow-up (LTFU) safety study of adult participants with prostate cancer that have received at least one dose of AAA617 from parent interventional Novartis sponsored clinical trials.