CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 30 enrolled
Drug / intervention
CX-4945drug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05817708
NCT05817708Phase 1Completed

A Dose Selection Phase 1 Study Evaluating the Safety and Tolerability of Silmitasertib

Senhwa Biosciences, Inc.·interventional·Posted Apr 18, 2023·Updated Jan 27, 2025

In Brief

A Phase 1 clinical trial evaluating CX-4945 for COVID-19. Completed, enrolled 30 participants across 1 site.

Detailed Summary

This is a Phase I single center, open-label, parallel design in 30 subjects to evaluate safety and tolerability of CX-4945 200mg QD, 200 mg BID and 400mg BID doses (10 subjects in each regimen) for continuously 5 days in healthy subjects for dose selection.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCOVID-19
CountriesTaiwan
Collaborators--

Timeline

Phase 1CompletedFinished
2023202420252026
First PostedApr 18, 2023
Enrollment StartNov 28, 2022
Primary CompletionMar 23, 2023
Study CompletionJun 20, 2023
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 3.2 years ago

Interventions

CX-4945drug

Drug: CX-4945 Silmitasertib, orally, once or twice daily for 5 days. Other Name: Silmitasertib