CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 893 enrolled
Drug / intervention
Proton pump inhibitor +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05817721
NCT05817721N/ACompleted
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PROTon Pump Inhibitors and Stent OCclusion Rate Of Lumen Apposing Metal Stents (PROTOCOL)

University Medical Center Goettingen·observational·Posted Apr 18, 2023·Updated Jun 15, 2025

In Brief

An observational study evaluating Proton pump inhibitor and LAMS-implantation for Acute Pancreatitis. Completed, enrolled 893 participants across 1 site.

Detailed Summary

The goal of this observational retrospective cohort study in combination with an expert study is to assess the clinical relevance and management of Lumen apposing metal stent (LAMS)-occlusion and LAMS-occlusion-related complications as well as the influence of proton pump inhibitors (PPI) on LAMS-occlusion. The main questions this study aims to answer are: * the individual management of LAMS-occlusion and LAMS-occlusion-related complications in the respective centers participating in the study. * if there is an association between PPI-intake and LAMS-occlusion and endoscopic necrosectomies. Participants for the retrospective cohort study will be enrolled retrospectively among European centers with expertise in pancreatology. The expert survey will be distributed European-wide to centers with special expertise in pancreatology.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Pancreatitis
CountriesGermany
CollaboratorsTechnical University of Munich, Ludwig-Maximilians - University of Munich, University Hospital in Halle, University of Leipzig, University Hospital Heidelberg, Landesklinikum Sankt Polten, University Hospital, Aachen, University of Oldenburg, University of Newcastle Upon-Tyne, Szeged University, University of Pecs, Semmelweis University, University of Ulm, University Hospital Olomouc, Brno University Hospital, University Hospital Regensburg, Klinikum Stadt Hanau, University Medicine Greifswald

Timeline

N/ACompletedFinished
202420252026
First PostedApr 18, 2023
Enrollment StartMay 5, 2023
Primary CompletionMar 29, 2024
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 3.2 years ago

Interventions

Proton pump inhibitordrug

Patients who received a lumen apposing metal stent (LAMS) for drainage of a walled off necrosis (WON) upon acute pancreatitis will be divided into a PPI/Non-PPI group depending on if they concomitantly were prescribed a PPI or not

LAMS-implantationdevice

Patients who received a lumen apposing metal stent (LAMS) for drainage of a walled off necrosis (WON) upon acute pancreatitis