CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 124 enrolled
Drug / intervention
Refresh Plus Preservative-free Lubricant Eye Dropsdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05832996
NCT05832996Phase 4Completed

Randomized Controlled Study of Cooled Versus Room-Temperature Artificial Tears for Reducing Surface Irritation Following Intravitreal Injection

University of Iowa·interventional·Posted Apr 27, 2023·Updated Mar 4, 2025

In Brief

A Phase 4 clinical trial evaluating Refresh Plus Preservative-free Lubricant Eye Drops for Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis) and 6 related conditions. Completed, enrolled 124 participants across 1 site.

Detailed Summary

Background and Objective: To evaluate the efficacy of cooled versus room temperature artificial tears in reducing post intravitreal injection (IVI) ocular discomfort. Patients and Methods: Patients receiving IVI were randomized to either cooled or room temperature tears intervention groups. Both groups rated their ocular discomfort following IVI before intervention and again after administration of cooled or room temperature tears.

Study Details

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedApr 27, 2023
Enrollment StartMar 1, 2022
Primary CompletionJul 1, 2022
Study CompletionJul 6, 2022
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 3.2 years ago

Interventions

Refresh Plus Preservative-free Lubricant Eye Dropsdrug

Refresh Plus Preservative-free Lubricant Eye Drops at either 4 or 25 degree Celsius