At a glance
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Feasibility Study of Using Fecal Microbiota Transplants (FMT) in Supportive Treatment of Anorexia Nervosa
In Brief
A Early Phase 1 clinical trial evaluating Fecal Microbiome Transplant for Anorexia Nervosa and Microbiome Dysbiosis. Completed, enrolled 17 participants across 3 sites.
Detailed Summary
The investigators hypothesize that prolonged undernutrition in anorexia nervosa alters the microbiome to a different steady-state (dysbiotic) composition that sustains the disease, even after returning to normal diet. The investigators propose that transplanting a fully ecologically functioning GM from a healthy donor, through a FMT, can reboot the gut-brain-axis, ameliorate symptoms and improve clinical outcomes. To approach this, in the challenging AN patient group, the investigators want to conduct a FMT feasibility/pilot study.
Study Details
Timeline
Interventions
Fecal matter from healthy age/sex matched established and screened donors, recruited from the Danish Blood-donor system