CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 160 enrolled
Drug / intervention
Transcutaneous vagal nerve stimulationdevice
Likely dose
Transcutaneous vagal nerve stimulation at 0.5 mA stimulus intensity, 25 Hz frequency applied to outer auditory canalAI-extracted
Key inclusion· 3
  • Fluent in English
  • In a relationship with partner for at least one year
  • Age 18-39 years
Key exclusion· 6
  • Major chronic disease including autoimmune disease, severe asthma, lung disease, history of stroke, heart attack, epilepsy, or brain injury
  • Cardiovascular disease
  • Cancer unless in remission
  • Current or long history (≥5 years) of substance dependence

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05899413
NCT05899413N/ACompleted

Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding

University of California, San Francisco·interventional·Posted Jun 12, 2023·Updated May 4, 2025

In Brief

A clinical study evaluating Transcutaneous vagal nerve stimulation for Vagus Nerve Stimulation. Completed, enrolled 160 participants across 1 site.

Detailed Summary

This study aims to understand the role of the vagus nerve in promoting social bonding by using a non-invasive stimulation technique called transcutaneous vagal nerve stimulation (tVNS). The investigators will investigate whether tVNS can improve emotional, physiological, and behavioral experiences during and after social interactions. Couples will be randomly assigned to receive either tVNS or a sham stimulation during gratitude expression and problem-solving discussions. The investigators will measure their subjective evaluations of the interactions and capture their physiological and behavioral synchrony. This research will shed light on the processes involved in social connection and explore the potential of tVNS as a tool to enhance bonding in close relationships.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
202420252026
First PostedJun 12, 2023
Enrollment StartFeb 17, 2024
Primary CompletionJul 31, 2024
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 3.1 years ago

Interventions

Transcutaneous vagal nerve stimulationdevice

The intervention consists of neurostimulation device that is programmed to a stimulus intensity at 0.5mA with a stimulation frequency of 25 Hz at the outer auditory canal.