CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 15 enrolled
Drug / intervention
Forced and Voluntary Exerciseother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05905302
NCT05905302N/ACompleted
CompareCT.gov

The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease

Jay Alberts·interventional·Posted Jun 15, 2023·Updated Dec 23, 2025

In Brief

A clinical study evaluating Forced and Voluntary Exercise for Parkinson Disease and Deep Brain Stimulation. Completed, enrolled 15 participants across 1 site.

Detailed Summary

Fifteen PwPD who have undergone DBS surgery and utilize the Percept system will complete a FE and VE exercise session on a stationary cycle while Off antiparkinsonian medication. Bilateral neural activity of the STN will be continuously recorded for 130 minutes (pre-, during FE or VE and post-exercise). The Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III Motor Exam and upper extremity force-tracking task will be used to determine motor response to exercise.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsParkinson Disease, Deep Brain Stimulation
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202420252026
First PostedJun 15, 2023
Enrollment StartAug 15, 2023
Primary CompletionSep 20, 2024
TodayJul 2, 2026
Enrollment to primary: 1.1 yearsPosted 3.0 years ago

Interventions

Forced and Voluntary Exerciseother

Participants will complete a forced exercise (FE) and voluntary exercise (VE) session. Forced exercise is a mode of high intensity exercise in which voluntary exercise rate is augmented, but not replaced. Voluntary exercise is standard stationary cycling. FE and VE exercise sessions will be Off antiparkinsonian medication. The order in which exercise session is conducted first will be randomized. Bilateral neural activity of the STN will be continuously recorded for 130 minutes (pre, during FE or VE and post-exercise).