CI

At a glance

ClinicalIndex Comparison Record
N/ARecruiting· 40 target
Drug / intervention
hypofractionationradiation
Likely dose
Not stated in record
Key inclusion· 3
  • Adult patients age 18 or older
  • Primary or locally recurrent extremity or truncal soft tissue sarcoma
  • ECOG performance status 0-2
Key exclusion· 6
  • History of prior local radiation therapy
  • Inability to tolerate treatment position during simulation or treatment
  • Tumor originating in retroperitoneal location
  • Planned systemic therapy including chemotherapy, targeted agents, and immunotherapy

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05917301
NCT05917301N/ARecruitingOn TrackUpdated 2mo ago

PROspective Phase II Trial of Pre-operative Hypofractionated protoN Therapy for Extremity and Truncal Soft Tissue sarcOma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins·interventional·Posted Jun 23, 2023·Updated Apr 17, 2026

In Brief

A clinical study evaluating hypofractionation for Soft Tissue Sarcoma. Currently recruiting, targeting 40 participants across 1 site.

Detailed Summary

This study is being done to examine whether proton therapy for certain kinds of sarcomas (extremity and trunk soft tissue) is safe and effective. As part of the study, patients will have five fractions of proton therapy before the participants have surgery for the sarcoma. The study will measure wound complications and functional outcomes / quality of life after the procedures. Patients will be asked to complete questionnaires about the treatment and quality of life from the time of enrollment until about two years after surgery. Otherwise, the participants will have standard of care follow ups with the treatment team.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ARecruiting
2024202520262027202820292030203120322033
First PostedJun 23, 2023
Enrollment StartApr 18, 2024
Primary CompletionDec 1, 2030
Study CompletionDec 1, 2032
TodayJul 2, 2026
Enrollment to primary: 6.6 yearsPosted 3.0 years agoPrimary completion in 4.4 years

Interventions

hypofractionationradiation

This study is being done to see if hypofractionation in treating sarcoma, will also provide patients with a faster and safer treatment outcome.