CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 88 enrolled
Drug / intervention
L-methylfolate +2 moredietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05931965
NCT05931965N/ACompleted
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Comparative Efficacy of Antidepressants With L-methylfolate, B12, and Magnesium in Depressive Disorders

Riphah International University·interventional·Posted Jul 6, 2023·Updated Sep 11, 2023

In Brief

A clinical study evaluating L-methylfolate, Vitamin B12, and 1 other intervention for Depression. Completed, enrolled 88 participants across 1 site.

Detailed Summary

The aim of this clinical trial is to compare the effect of antidepressants in combination with different dietary supplements in patients with depression. Our main objective is to compare the efficacy of antidepressants in combination with either L-methyl folate, Vit B12, or magnesium) in patients with depressive disorders. The levels of depressive symptoms as measured by the Patient Health Questionnaire (PHQ-9) at base level and during follow-up.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
CountriesPakistan
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedJul 6, 2023
Enrollment StartOct 5, 2022
Primary CompletionJul 30, 2023
Study CompletionAug 31, 2023
TodayJul 2, 2026
Enrollment to primary: 10 monthsPosted 3.0 years ago

Interventions

L-methylfolatedietary

Participants receive L-methylfolate 400µg orally twice daily for 4 weeks

Vitamin B12dietary

Participants receive mecobalamin 500µg intramuscularly stat on alternate days (6 total injections)

magnesiumdietary

Participants receive magnesium glycinate 400mg twice daily orally for 4 weeks (elemental 120mg approx.)