CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 31 enrolled
Drug / intervention
E-liquid coolant (WS-3, 0.05%) +15 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05932693
NCT05932693N/ACompleted
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Examine the Effects of Novel E-cigarette Constituents and Determining Appropriate Concentrations Among Adults

Yale University·interventional·Posted Jul 6, 2023·Updated Feb 18, 2026

In Brief

A clinical study evaluating E-liquid coolant (WS-3, 0.05%), E-liquid coolant (WS-3, 0.1%), and 14 other interventions for E-Cig Use. Completed, enrolled 31 participants across 1 site.

Detailed Summary

This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsE-Cig Use
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

N/ACompletedFinished
202420252026
First PostedJul 6, 2023
Enrollment StartSep 3, 2024
Primary CompletionJan 9, 2025
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 3.0 years ago

Interventions

E-liquid coolant (WS-3, 0.05%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.05%.

E-liquid coolant (WS-3, 0.1%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.1%.

E-liquid coolant (WS-3, 0.5%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.5%.

E-liquid coolant (WS-3, 1.0%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 1.0%.

E-liquid coolant (WS-3, 2.0%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 2.0%.

E-liquid coolant (menthol, 0.05%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.05%.

E-liquid coolant (menthol, 0.1%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.1%.

E-liquid coolant (menthol, 0.5%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.5%.

E-liquid coolant (menthol, 1.0%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 1.0%.

E-liquid coolant (menthol, 2.0%)other

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 2.0%.

E-liquid coolant (WS-23, 0.05%)other

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.05%.

E-liquid coolant (WS-23, 0.1%)other

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.1%.

E-liquid coolant (WS-23, 0.5%)other

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.5%.

E-liquid coolant (WS-23, 1.0%)other

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 1.0%.

E-liquid coolant (WS-23, 2.0%)other

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 2.0%.

E-liquid coolant (WS-23, 4.0%)other

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 4.0%.