CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 122 enrolled
Drug / intervention
Manual Therapyother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05940012
NCT05940012N/ACompleted

Specific and Shared Mechanisms Associated With Physical Therapy Interventions

Duke University·interventional·Posted Jul 11, 2023·Updated Nov 18, 2025

In Brief

A clinical study evaluating Manual Therapy for Chronic Neck Pain. Completed, enrolled 122 participants across 1 site.

Detailed Summary

It is expected that different physical therapy treatments influence outcomes in many different ways. Each treatment is assumed to have a "specific" treatment mechanism, which explains how that specific treatment works. Different treatments also have "shared" mechanisms, which are similar across many different types of interventions (e.g., exercise, cognitive treatments or manual therapy). In this study, the study team will investigate the several types of specific treatment mechanisms of a manual therapy-based approach and an exercise-based approach and the study team will compare these to see if they are different. The patient population will include individuals with chronic neck pain, which is a condition that leads to notable disability and pain. The study team will also evaluate several shared treatment mechanisms to see if these are similar across the two treatments (e.g., manual therapy versus exercise). The study team expects to find that there are some specific treatment mechanisms with each approach (manual therapy versus exercise) but also several "shared" mechanisms that are similar across the two seemingly different approaches. These will likely influence the outcomes and may help explain why clinicians see similar outcomes across both treatment groups for chronic neck pain. This study is important because no one has investigated whether the outcomes that occur with chronic neck pain are mostly influenced by specific or shared treatment mechanisms. Interestingly, in the psychological literature, shared treatment mechanisms demonstrate the strongest influence (more than specific treatment mechanisms).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
202420252026
First PostedJul 11, 2023
Enrollment StartJan 1, 2024
Primary CompletionApr 30, 2025
Study CompletionOct 22, 2025
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 3.0 years ago

Interventions

Manual Therapyother

Hands on treatments including manipulation, mobilization and soft-tissue mobilization with therapeutic intent.