CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 5,747 enrolled / 5,747 target
Drug / intervention
TASKPENother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05950919
NCT05950919N/ACompletedHigh Momentum (154.9/mo)Completion was 6mo ago

Z 32201 - Effects of a Package of Evidence-based Interventions and Implementation Strategies Based on WHO PEN for People Living With HIV and Cardio-metabolic Conditions in Lusaka, Zambia: A Type II Hybrid Effectiveness-implementation Stepped Wedge Trial

University of North Carolina, Chapel Hill·interventional·Posted Jul 18, 2023·Updated Jun 29, 2026

In Brief

A clinical study evaluating TASKPEN for HIV and Non Communicable Diseases. Completed, enrolled 5,747 participants across 12 sites.

Signals

Enrolling ahead of pace

Detailed Summary

The purpose of this study is to evaluate the effects of a multi-level intervention known as "TASKPEN," adapted from the World Health Organization (WHO) Package of Essential Noncommunicable Disease Interventions (WHO-PEN) for the Zambian public health system, on clinical and implementation outcomes for persons living with HIV (PLHIV) with co-morbid cardio-metabolic conditions in Lusaka, Zambia.

Study Details

Timeline

N/ACompletedFinished
202420252026
First PostedJul 18, 2023
Enrollment StartMay 30, 2023
Primary CompletionDec 31, 2025
TodayJul 2, 2026
Enrollment to primary: 2.6 yearsPosted 3.0 years ago

Arms & Interventions

TASKPENexperimental

The TASKPEN intervention is a package of five evidence-based intervention (EBI) components that enhances WHO's Package of Essential Noncommunicable Disease Intervention for Primary Care (WHO-PEN) and includes a multi-faceted implementation strategy centred on service integration within routine HIV care settings. The EBI components and multi-faceted strategy have been adapted to the Zambian setting during recently completed formative work."

Other: TASKPEN
Standard of Careno_intervention

Screening, diagnosis, and treatment of cardio-metabolic NCDs are generally unavailable in the clinical departments where most PLHIV seek and receive health services. When these services are available, they tend to be siloed and offered only for hypertension in general outpatient medical settings that provide urgent care-like services. Healthcare workers do not have protocolized algorithms for NCD management in HIV service delivery settings. NCD equipment is often unavailable in ART and differentiated service delivery (DSD) clinics; most health facilities do not offer haemoglobin A1c or lipid panel testing; and fragmented NCD supply chain management systems mean that essential medications for the management of hypertension, diabetes, and dyslipidemia are often unavailable

Interventions

TASKPENother

The package of integrated HIV/NCD services: 1. Integrated non-communicable/HIV care ("one stop shop" for services) 2. WHO PEN protocols, algorithm, \& training materials adapted for Zambia 3. Access to cardio-metabolic condition screening \& laboratory monitoring 4. Non-communicable disease-focused electronic medical record module 5. Strengthened NCD medication supply chain