CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 116 enrolled
Drug / intervention
Direct Milk antigen reintroduction +1 moredietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05960045
NCT05960045N/ACompleted

Testing Tolerance in Cow Milk Protein Allergy Patients: Milk Ladder or Direct Milk Administration?

Ain Shams University·interventional·Posted Jul 25, 2023·Updated May 7, 2025

In Brief

A clinical study evaluating Direct Milk antigen reintroduction and Milk ladder for Cow Milk Allergy and Tolerance. Completed, enrolled 116 participants across 1 site.

Detailed Summary

Majority of children outgrow their allergies, however there are two different methods to re-introduce milk products in the infant diet either direct milk intake in escalating doses or milk ladder, starting with baked milk products instead of pure milk. This study aims to compare rate of tolerance after milk reintroduction among patient with cow milk protein allergy (CMPA) diagnosed by elimination re-challenge test after six months of elimination diet by milk ladder versus direct milk intake.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesEgypt
Collaborators--

Timeline

N/ACompletedFinished
202420252026
First PostedJul 25, 2023
Enrollment StartJul 1, 2024
Primary CompletionApr 15, 2025
Study CompletionApr 28, 2025
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 2.9 years ago

Interventions

Direct Milk antigen reintroductiondietary

Direct milk antigen re-introduction milk according to ESPGHAN guidelines

Milk ladderdietary

B: Milk ladder according to the iMAP guideline which are 6 weeks of gradual reintroduction starting with baked milk not direct antigen