CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 84 enrolled
Drug / intervention
Dexamethasone +6 moredrug
Likely dose
Dexamethasone 10mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05974501
NCT05974501Phase 4Completed

Pre vs. Postoperative Adductor Canal Block for Total Knee Arthroplasty: Prospective Randomized Trial

University of Miami·interventional·Posted Aug 3, 2023·Updated Feb 12, 2025

In Brief

A Phase 4 clinical trial evaluating Dexamethasone, Acetaminophen, and 5 other interventions for Knee Osteoarthritis and 2 related conditions. Completed, enrolled 84 participants across 1 site.

Detailed Summary

The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee arthroplasty can be observed with the substitution of a post operative adductor canal block for a preoperative adductor canal block in the current established peri-operative pain protocol and if these changes lead to a decrease in opioid consumption (in morphine equivalents).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
202420252026
First PostedAug 3, 2023
Enrollment StartSep 29, 2023
Primary CompletionJan 22, 2024
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 2.9 years ago

Interventions

Dexamethasonedrug

Dexamethasone 10mg administered via IV once postoperatively within 24 hours for pain and swelling

Acetaminophendrug

1,000mg administered via tablet every 8 hours for pain during the first 1-2 weeks postoperatively

Lyricadrug

Administered via tablet 75mg nightly for pain during the first 1-2 weeks postoperatively

Celebrexdrug

200mg administered via tablet twice a day for pain and swelling during the first 1-2 weeks postoperatively

Meloxicamdrug

30mg administered via IV once postoperatively within 24 hours for pain and swelling

Oxycodonedrug

5mg administered via tablet every 4 hours as needed for pain during the first 1-2 weeks postoperatively

Ropivacainedrug

20 milliliters Ropivacaine 0.2% administered via injection perioperatively.