At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase 1, Open-Label, Two-Part, Fixed-Sequence, Drug-Drug Interaction Study to Evaluate the Effect of Voxelotor on the Pharmacokinetics of Selected CYP and Transporter Probe Substrates in Healthy Participants
In Brief
A Phase 1 clinical trial evaluating Voxelotor, Bupropion, and 7 other interventions for Sickle Cell Disease. Completed, enrolled 44 participants across 1 site.
Detailed Summary
This research study is examining multiple doses of voxelotor (a study drug intended for treatment of sickle cell disease) and how it interacts with additional substrates (substrates are drugs or other substances that are metabolized by cytochrome enzymes. The substrates used in this study are FDA approved medications). The study will help to determine the safety and tolerability of the study drugs taken together, as well as the pharmacokinetics (PK) on how your body processes and responds to the combination of the study drug and substrates. Although these drugs are FDA approved, their use in this study is experimental.
Study Details
Timeline
Interventions
Drug drug interaction
Drug drug interaction
Drug drug interaction
Drug drug interaction
Drug drug interaction
Drug drug interaction
Drug drug interaction
Drug drug interaction
Drug drug interaction