CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 96 enrolled
Drug / intervention
Psychopharmacological Intervention +3 moredrug
Likely dose
Psychopharmacological Intervention 10 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06001021
NCT06001021N/ACompleted

The Effectiveness of Psychopharmacological Intervention Versus Cognitive Behavioral Couple Therapy and Their Combination in Perinatal Distressed Couples: A Randomized Clinical Trial

Sameera Shafiq·interventional·Posted Aug 21, 2023·Updated Aug 13, 2025

In Brief

A clinical study evaluating Psychopharmacological Intervention, Cognitive Behavioral Couple Therapy, and 2 other interventions for Perinatal Depression and Perinatal Anxiety. Completed, enrolled 96 participants across 1 site.

Detailed Summary

The hypotheses of the study are * There will be differences in perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being in couples at Pre- and Post-Test levels during the perinatal period in couples. * There will be differences with psychopharmacological intervention on total scores of perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being between the experimental and wait list-placebo control groups. * There will be differences in CBCT (condition: without Zikr) on total scores of perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being between the experimental and wait list control group. * There will be differences in CBCT (condition: with Zikr) on total scores of perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being between the experimental and wait list-placebo control groups. * There will be differences for combined psychopharmacology, and CBT (conditions: with Zikr, without Zikr ) dimensions on total scores of perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being between experimental and wait list-placebo control group.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesPakistan
Collaborators--

Timeline

N/ACompletedFinished
202420252026
First PostedAug 21, 2023
Enrollment StartAug 15, 2023
Primary CompletionSep 30, 2023
Study CompletionOct 28, 2023
TodayJul 2, 2026
Enrollment to primary: 2 monthsPosted 2.9 years ago

Interventions

Psychopharmacological Interventiondrug

Escitalopram 5-10 mg in antenatal period; Sertraline 12.5-25 mg in postnatal period) and/or Benzodiazepine (Alprazolam, 0.25-0.50 mg).

Cognitive Behavioral Couple Therapybehavioral

CBCT intervention from a trained psychologist in CBT.

Combination of Psychopharmacological Intervention and CBCTother

Medication will be prescribed by a consultant gynecologist and CBCT (conditions: with or without Zikr) will be provided by a trained psychologist.

Placebo and No Interventionother

Control waitlist group will be provided with either a placebo by a consultant gynaecologist or no intervention by a trained psychologist