At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.
In Brief
A Phase 4 clinical trial evaluating Ketamine-Morphine and Morphine for Ketamine and Morphine. Completed, enrolled 60 participants across 1 site.
Detailed Summary
The goal of this clinical trial is to compare the effectiveness of PCA ketamine-morphine versus conventional PCA morphine in postoperative patients undergoing elective laparotomy colorectal surgery under general anaesthesia. The specific objectives are: 1. To compare the postoperative analgesic requirement with PCA ketamine-morphine in comparison with PCA morphine. 2. To compare the postoperative pain scores between PCA ketamine-morphine and PCA morphine. 3. To assess patients' overall satisfaction with PCA ketamine-morphine in comparison with PCA morphine. 4. To study the incidence of side effects of PCA ketamine-morphine in comparison with PCA morphine. Participants will be screened and recruited at the pre-anaesthetic clinic (PAC). Those who consented will be taught to use the PCA machine and the potential side effects of the study drugs. They will be randomly allocated into either Group A or Group B by computer-generated randomization a day before planned surgery. Researchers will compare Group A and Group B to see post-operative pain scores, patients' overall satisfaction and any incidence of side effects.
Study Details
Timeline
Interventions
PCA ketamine (Ketamine HCl, Pfizer Inc., US) 0.5 mg plus morphine 0.5 mg ml-1 (ratio 1:1)
PCA morphine (Pfizer Inc., US) 1 mg ml-1